Jarisch-Herxheimer Reaction

Jarisch-Herxheimer Reaction Facts:

• Is a reaction due to bacterial endotoxins & microbial antigens which are liberated by microorganisms following their destruction.
• The reaction is not an indication to stop treatment because symptoms resolve with continued therapy.

Clinical Features:

• General - fever
• Skin - transient macular or urticarial eruptions, & exacerbation of preexisting skin lesions.
• Immune - tender lymphadenopathy
• Rheumatological - arthralgias

Aetiological Factors:

• Diethylcarbamazine therapy for oncocerciasis.
• Penicillin therapy for syphilis.
• Griseofulvin therapy for dermatophyte infections.
• Ketoconazole therapy for dermatophyte infections.

Tags: Dermatophyte Infection - Diethylcarbamazine - Endotoxin - Griseofulvin - Jarisch-Herxheimer Reaction - Ketoconazole - Onchocerciasis - Penicillin - Syphilis
Posted by Medicalchemy
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